What does it mean to be comfortable in your own skin? Did an itchy rash finally clear up or something and you can finally sleep at night? Is anybody ever more comfortable in someone else's skin? Maybe if it was a bear skin and you were trying to survive a harsh winter and it didn't smell too bad. It's also okay to wear cute rabbit skin boots in the winter. Otherwise, it's just creepy to wear another's skin.
Unless it's a leather jacket. It's always stylish to wear the skin of a dead bovine, even if you're one of those PETA types or a vegan.